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While the peptides activation of ENC-alpha in the lungs is a good thing in pneumonia where fluid literally interferes with breathing, the investigators were concerned that activating ENaC-alpha in the kidneys might disturb normal sodium retention, which is important to the kidneys role in blood pressure regulation

1 These eight dimeric enzymes are categorized as alpha (A), kappa (K), mu (M), omega (O), pi ( p ), sigma (S), theta (T), and zeta (Z) based on their amino acid sequences and substrate specificity

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